Well I was just thinking what would happen if Jiraya went up against Tsunade without Shizune. Person all I think Tsunade would win it will say why I think Tsunade will win in the spoiler thing button
Ok Tsunade would probally win because In the Shipuuden it Jiraya says that he almost got killed twice one by Tsunade because she saw him peeping in the ladies hot springs

So thats why I think that Tsunade would win But I don't know for sure:)