Marvel 2099 was a Marvel Comics imprint launched in 1993 at the verge of the collapse of the late-80s-early-90s speculator boom. It was originally announced by Stan Lee in his "Stan's Soapbox" column as a single series entitled The Marvel World of Tomorrow which was under development by Lee and John Byrne. This concept later changed to a line of books under the banner "Marvel 2093" (the date being one hundred years from the year in which the titles were to have launched) before finally being published as "Marvel 2099," which apparently just sounded cooler.

From the start, the 2099 Universe was designed to be a so-called "shared universe" featuring a tight-knit continuity. Unlike Marvel's previous shared universe imprint, the New Universe (and possibly in response to the lessons learned from it's publication), Marvel spared no expense in publishing the 2099 books. Like the New Universe, 2099 was promoted heavily but unlike that previous imprint, money was spent on getting some of the best writers and artists working in the industry. Unlike many imprints from the period, the 2099 books didn't have a "house style" and as a result the variety of art styles had a more "mainstream" feel. The line was edited by Joey Cavalieri.

Three of the launch titles (Doom 2099, The Punisher 2099, and Spider-Man 2099) starred "futuristic" takes on pre-existing characters while the fourth, Ravage 2099, featured an all-new superhero scripted for several months by Lee himself. The 2099 line soon expanded to include 2099 Unlimited (an anthology), Fantastic Four 2099, Ghost Rider 2099, Hulk 2099, X-Men 2099, and X-Nation 2099. The books were fairly well received initially, especially Spider-Man 2099, but soon had an uphill battle to fight when the speculator bubble popped soon after launch and overall comic sales began to plummet. In 1996, Cavalieri was let go, apparently as a cost-cutting measure.

In protest, many of the imprint's creative people quit, including Spider-Man 2099's Peter David and Doom 2099's Warren Ellis. This marked the downfall of the struggling imprint. All of the 2099 titles were soon cancelled and replaced by 2099: World of Tomorrow, a single title featuring the surviving characters from all the titles. It lasted only eight issues before being cancelled itself. The 2099 line was finally concluded with a one-shot, 2099: Manifest Destiny, cover dated March 1998. The story summarised the future of the 2099 Universe in the years from 2099 to 3099. This final chapter of the 2099 Universe's publishing history (1996 - early 1998) would also see Marvel, one of the world's largest comic book publishers, file for bankruptcy. It would also mark the end of the speculator crash.

The world of 2099 is a cyberpunk dystopia mixed with Marvel's typical superhero offerings. In the stories, North America is a corporate police state ruled by a few huge megacorporations. In this world there are no active superheroes. The old heroes of present-day Marvel are mythologized and even worshipped, as with the Church of Thor. In the 2099 Universe, this past "Age of Heroes" ended in cataclysm.

In 2004, writer Robert Kirkman wrote a series of one-shot comics for the fifth anniversary of the Marvel Knights imprint, under the banner of "Marvel Knights 2099." The future portrayed in this series is divergent from the original 2099 Universe.

In 2006, the Exiles visited the 2099 Universe as part of their "World Tour" arc. This version of the 2099 future is also divergent from the original 2099 Universe. It is clear that it split apart from the mainstream 2099 Universe fairly early since Doom 2099 has not yet met Spider-Man 2099 in this story. The Spider-Man 2099 of this future joined the Exiles and was featured in that title (the 2001 vintage) from issue 75 to 99 and Annual 1.