There is a consensus amongst the Sannin fans that they can react to Ay's or Bee's speed, which I'm making this thread to crush this idea. 1). Here is Tsunade stating she can't believe KCM Naruto can keep up with Ay's speed: 2). When Ay states he's going to kill Naruto, Tsunade aims to step in only to fail because she is too slow: As indicated by the drawn motion line, she was attempting to move fast to save Naruto but couldn't make it in time because she was slow, and Bee had to step in because he was fast. The exclamation mark even shows she had no idea what happened, because everything was happening too fast. Given both Jiraiya and Orochimaru scale to her, and she has better CQC feats than both; in that same scenario in midst of battle Ay or Kirabi can blitz them easily.