I have always been told that Jiraiya can destroy Itachi in a fight, I didn't quite see why he would untill some one told me the truth. They explained to me that Jiraiya's frogs can cancel out Itachi's genjutsu. I was suprised and elated.....wait no I wasn't. Anyway, I pondered how the old pervert's frogs by themselves could defeat someone with such plot importance as Itachi then it dawned on me. Jiraiya can summon the Hypnotoad. Itachi's genjutsu is shit conpared to this little fellow's mind control, I even question if God(aka Sandaime prime) could resist it's glare. For more sources on the hypnotoad go here and here Sidoro And here Here is a fun fact: the Hypnotoad is harder to control then Gama bunta.