The question is multifaceted. Like his sharingan is so evolved that even if you are 3x as fast as him it does not matter because he already knows your attacks before you launch(as seen in the VOTE figt, Naruto is in One Tail mode, he is like 3-4x times faster than Sasuke and if he did not have the premonition from the Sharingan he would have been beaten to the ground) Itachis hand seal speed is probably the fastest in the Narutoverse, so beating him with Nin Jutsus is probably hard, and his Sharingan can probably copy most of your Nin Jutsus anyway, so he can your trump card Then we have Mangekyou Sharingan, Tsukuyomi a Genjutsu who is applied through eye contact, and is finished in 1 second(is there a range for this, like 5 meters or seomthing?) or could he like snipe people from long distances with it. Amaterasu burns through mostly everything, and burns for a long time. The question is, if he has no weaknesses from Taijustsu, Ninjutsu or Genjutsu. He is in my opinion a very boring character who brings little to nothing to the overall plot.